Product Introduction

Agmatine is a common natural compound synthesized by decarboxylation of the amino acid arginine, so it is also known as decarboxylated arginine. Agmatine has been shown to exert modulatory action at multiple molecular targets like: neurotransmitter systems, key ion channels, nitric oxide (NO) synthesis and polyamine metabolism. Agmatine has also been discussed as a putative neurotransmitter/neuromodulator. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase.Normally it is sold as Agmatine sulfate on the market in the field of bodybuilding supplement, health food addtive, pharmacology.

Effects/Benefit/Uses

Agmatine Sulfate was mainly marketed as a supplement of bodybuilding for many years. Research shows it can enhance muscle pumps, better nutrient partitioning, and increased production of lutenizing hormone and growth hormone.

Agmatine biosynthesis by arginine decarboxylation is well-positioned to compete with the principal arginine-dependent pathways, namely: nitrogen metabolism (urea cycle), and polyamine and nitric oxide (NO) synthesis (see illustration 'Agmatine Metabolic Pathways'). Agmatine degradation occurs mainly by hydrolysis, catalyzed by agmatinase into urea and putrescine, the diamine precursor of polyamine biosynthesis. An alternative pathway, mainly in peripheral tissues, is by diamine oxidase-catalyzed oxidation into agmatine-aldehyde, which is in turn converted by aldehyde dehydrogenase into guanidinobutyrate and secreted by the kidneys

Other potential Medical uses including:

• Cardivascular

• Glucose regulation

• Enhance kidney functions

• Neurotransmission

Side effects and Dosage:

Agmatine Sulfate appears to have few side effects due to the reports so far. The most relevant study tested safety of agmatine sulfate in doses ranging from 1.335 g per day to 3.560 g per day. Most study participants had no side effects from taking agmatine sulfate. Only 3 people in the highest dosing regimen experienced mild or moderate diarrhea and nausea.

Reference:

http://www.webmd.com/search/search_results/default.aspx?query=Agmatine

http://www.supplementing.com/agmatine-sulfate/#references