Introduction

Nicotinamide riboside, also know as NR, was firstly described in 1944 as a growth Factor as Factor V. The purified form  blood Factor V exist in three forms: NAD+,NMN and NR. Nicotinamide riboside(NR) is a nutrual Vitamin can be found in Cow  milk which is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide (NAD)

As we know,Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for enzymes involved in the  beneficial effects of regular calorie restriction on healthspan. As such, the use of NAD+ precursors like Nicotinamide  riboside(NR) or NMN to augment NAD+ bioavailability has been proposed as a strategy for improving cardiovascular and other  physiological functions with aging in humans.

Initial studies have clarified the potential for nicotinamide riboside(NR) that is available in selected foods, and  possibly available to humans by supplements. It has properties that are insulin sensitizing, enhancing to exercise,  resisting to negative effects of high-fat diet, and neuroprotecting. So currently Nicotinamide riboside(NR) has been  available on the market as a Anti-aging health supplements and in 2016 the FDA granted generally recognized as safe (GRAS)  status for nicotinamide riboside as a food ingredient in enhanced water products, protein shakes, nutrition bars, gum and  chews at no more than 0.027% of NR by weight.[3] The NOAEL and LOAEL in rodents are 300 and 1,000 mg/kg/day respectively.

Natural Micron Lab are supplying high quality nicotinamide riboside(NR) raw powder to nutrition companies all over the  world. We can supply nicotinamide riboside(NR) in both food grade and pharmaceutical grade. Please feel free to contact us  if you have any inquiry!

Reference:

Vol. 28:115-130 (Volume publication date 21 August 2008) First published online as a Review in Advance on April 22, 2008.

https://www.annualreviews.org/doi/abs/10.1146/annurev.nutr.28.061807.155443

https://en.wikipedia.org/wiki/Nicotinamide_riboside

"Spherix/Chromadex GRAS submission" (PDF). March 8, 2016. Archived (PDF) from the original on March 4, 2017. See FDA GRAS  index page: "GRAS Notice (GRN) No. 635". Archived from the original on 2017-02-11.

https://www.ncbi.nlm.nih.gov/pubmed/24071780

https://www.nature.com/articles/s41467-018-03421-7#Sec2